Accession Number : AD0691175

Title :   INFLUENCE OF BETA SYMPATHETIC BLOCKADE (PROPRANOLOL) ON THE HEMODYNAMICS OF HYPERTHYROIDISM,

Corporate Author : NAVAL HOSPITAL PHILADELPHIA PA DEPT OF MEDICINE

Personal Author(s) : Wiener,Leslie ; Stout,Bill D. ; Cox,J. William

Report Date : 29 MAR 1968

Pagination or Media Count : 8

Abstract : The circulatory effects of propranolol (0.15 to 0.38 mg. per kg. given intravenously) were studied in seven hyperthyroid patients during periods of rest and exercise before and after the administration of propranolol and the results conpared with propranolol effects in euthyroid subjects. Indices of left ventricular work (LVWI); stroke work (SWI); left ventricular tension time (TTI); mean systolic ejection rate (MSER); and cardiac output (CI) were derived in the usual manner. The mean rate of left ventricular isovolumetric pressure development (MRIPD) was employed as an index of contractility. It was concluded that beta adrenergic blockade attenuates the positive inotropic and chronotropic effects of thyroid hormone and presumably reduces the exaggerated myocardial oxygen requirement of thyrotoxicosis. Myocardial efficiency is thereby improved. The study supports the concept that the cardiac effects of thyroid hormone are mediated at least in part via the sympathetic nervous system. (Author)

Descriptors :   (*THYROID GLAND, *SYMPATHOLYTIC AGENTS), DISEASES, BLOOD PRESSURE, HEART, BLOOD CIRCULATION, THYROID HORMONES, EXERCISE(PHYSIOLOGY), OXYGEN CONSUMPTION

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE