Accession Number : AD0692842

Title :   MODIFICATION OF THE EFFECTS OF ATROPINE ON HUMAN HEART RATE BY 2-PAMCl.

Descriptive Note : Technical rept. Nov-Dec 68,

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Sidell,Frederick R. ; Magness,Josephine S. ; Bollen,Thomas E.

Report Date : AUG 1969

Pagination or Media Count : 25

Abstract : Eight subjects each received atropine sulfate (2 mg/2 ml) and 2-PAMCl (600 mg/2 ml) in separately, simultaneously but in different injections, and in the same solution. Heart rates were counted as an indication of absorption of atropine. When the drugs were mixed before injection the time course of the heart rate response was delayed compared to the time course when the drugs were given simultaneously and separately. This suggests that the addition of 2-PAMCl to the atropine injection hinders the absorption of or impedes the action of atropine. (Author)

Descriptors :   (*ATROPINE, TOXICITY), (*CHEMICAL WARFARE AGENTS, ATROPINE), TOXIC TOLERANCES, HEART

Subject Categories : Toxicology
      Pharmacology
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE