Accession Number : AD0693310

Title :   EFFECTS OF ATROPINE ON THE COMPOSITION OF UNSTIMULATED HUMAN PAROTID FLUID.

Descriptive Note : Final rept. Dec 66-Sep 67,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Shannon,Ira L. ; Suddick,Richard P. ; Chauncey,Howard H. ; Segreto,Vincent A.

Report Date : JUN 1969

Pagination or Media Count : 16

Abstract : Unstimulated parotid fluid was collected from 300 healthy young adult males and, after atropine dosage, a second collection was made. Mean rate of flow decreased from 0.054 ml./min. to 0.018 ml./min after atropine administration. Highly significant (P < .01) increases were found for potassium, chloride, calcium, magnesium, phosphorus, amylase, acid phosphatase, uric acid, urea nitrogen, total protein, glucose, total solids, specific gravity, and osmolality. Sodium concentration and viscosity were not significantly affected by the decreased rate of gland function, but bicarbonate and pH decreased significantly (P < .01). Possible explanations for these changes involve, primarily, the outward diffusion of water down an osmotic gradient, and a decrease in glycolytic processes within the gland associated with the lowered rate of function. (Author)

Descriptors :   (*ATROPINE, BODY FLUIDS), (*BODY FLUIDS, *SALIVARY GLANDS), HUMANS, SECRETION, CHEMICAL ANALYSIS

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE