Accession Number : AD0693659

Title :   EXPERIMENTAL INVESTIGATION OF THE TOXICITY OF CERTAIN FLUOROAROMATIC COMPOUNDS,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Lapik,A. S. ; Zimina,L. N.

Report Date : 07 MAY 1969

Pagination or Media Count : 7

Abstract : The oral LD (Subscript 50) of the following compds. were detd. for white mice: benzaldehyde 1240, pentafluorobenzaldehyde 320, benzoic acid 2800, pentafluorobenzoic acid 2500, acetophenone 970, pentafluoroacetophenone 850, decafluorohydrobenzoin 485, dinitrodecafluorohydrobenzoin 5000, terephthalic acid 585, tetrafluoroterephthalic acid 350, di-Me tetrafluoroterephthalate 870, phthalic acid 560, tetrafluorophthalic acid (I) 320, di-Me I 780, pentafluorobromobenzene 959, bromopentafluoroacetophenone 350, Et pentafluorobenzoate 1700, benzophenone 1250, decafluorobenzophenone 960, decafluorobenzhydrol 1350, pentafluorobenzhydrol 1750, ester of decafluorobenzhydrol and HNO (subscript 3) 1750, tris(pentafluorophenyl)methane 1625, benzene 400, pentaflurorbenzene 710, pentafluorochlorobenzene 1250, octafluoronaphthalene 670, hexafluoro-1, 4-naphthoquinone 450, pentafluoropyridine 280, fluoranil 420 mg./kg. The toxic symptoms were generally similar: decreased motor activity, loss of coordination, paralysis, and death. The benzene derivs. had a narcotic effect and octafluoronaphthalene and pentafluoropyridine caused convulsions. (Author)

Descriptors :   (*FLUORINE COMPOUNDS, TOXICITY), (*AROMATIC COMPOUNDS, TOXICITY), (*HALOGENATED HYDROCARBONS, TOXICITY), TOXIC TOLERANCES, RATS, ALIPHATIC COMPOUNDS, BIOCHEMISTRY, DOSAGE, USSR

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE