Accession Number : AD0693814

Title :   PHYSIOLOGIC CONTROL OF CONCEPTION WITH AN INTRAMUSCULAR PROGESTOGEN-ESTROGEN: CLINICAL EXPERIENCE.

Descriptive Note : Final rept. May 65-Jun 68,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH SAN FRANCISCO CALIF

Personal Author(s) : Creasy,Robert K. ; Hillig,John E. ; Morris,John A.

Report Date : 25 AUG 1969

Pagination or Media Count : 15

Abstract : Thirty-eight women were treated over 353 cycles with an intramuscular contraceptive preparation, 150 mg dihydroxyprogesterone acetophenide and 10 mg estradiol enanthate. This has proved to be an effective anti-fertility agent. Only 5 subjects completed 24 cycles of therapy. This preparation shortened the menstrual cycles of all women and increased the duration of flow in all but 5. Twenty-six percent of the subjects discontinued therapy because of abnormal menstrual cycles. No alterations in renal function were noted in the 7 patients who remained in the study long enough for follow-up. Acceptance of the intramuscular contraceptive was not impressive, and the 'drop-out' rate was significant. It is concluded that this formulation is an effective contraceptive drug but it seems unlikely that it will supplant other modes presently in use for the majority of the populace. (Author)

Descriptors :   (*FERTILITY, CONTROL), PROGESTERONE, ESTROGENS, INJECTIONS(MEDICINE), MUSCLES, HORMONES, PHYSIOLOGY, REPRODUCTION(PHYSIOLOGY), DRUGS

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE