Accession Number : AD0693879

Title :   QUANTITATIVE STUDIES OF FLUID EXCHANGE AND BLOOD FLOW DURING HEMORRHAGIC SHOCK.

Descriptive Note : Annual progress rept. 1 May 68-1 May 69,

Corporate Author : CALIFORNIA UNIV SAN DIEGO LA JOLLA

Personal Author(s) : Zweifach,Benjamin W. ; Intaglietta,Marcos ; Fronek,Kitty ; Smaje,L. H.

Report Date : 15 MAY 1969

Pagination or Media Count : 42

Abstract : The progression of hemorrhagic shock was followed in rabbits, cats and dogs and data was obtained on the pressure distribution throughout the terminal vascular bed in the splanchnic mesentery on variations in colloid osmotic pressure of the blood, on changes in the filtration coefficient as an index of vascular permeability, and the efficacy of blood versus Ringer lactate as volume replacement measures. Compensatory adjustments attempt to keep capillary pressure constant in the face of a steadily falling plasma c.o.p. With profound hypotension (below 40 mm. Hg for several hours) the plasma c.o.p. frequently falls below 10 cm. H2O(normal = 20 - 22 cm. H2O). Recovery following either blood replacement or electrolyte infusions need not be associated with a restoration plasma c.o.p. to normal. In fact, r.b.c. + sodium lactate mixtures effectively restored flow to capillary bed even after 2 hours of severe hypotension. Subsequent repeated injections of concentrated albumin (25%) assisted in restoration of balance between hydrostatic and plasma colloid osmotic pressures. There was no significant increase in permeability coefficient following hemorrhage. Tendency for capillary pressure to rise because of ineffective outflow through venules will give rise to stasis of small veins and interferes with adequate perfusion of tissue during shock. (Author)

Descriptors :   (*SHOCK(PATHOLOGY), *HEMORRHAGE), (*BODY FLUIDS, SHOCK(PATHOLOGY)), (*BLOOD CIRCULATION, SHOCK(PATHOLOGY)), OSMOTIC PRESSURE, BLOOD PLASMA, BLOOD PRESSURE, BLOOD VOLUME, HYPOTENSION, PHYSIOLOGY, CARDIOVASCULAR SYSTEM, ELECTROLYTES(PHYSIOLOGY)

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE