Accession Number : AD0693890

Title :   BLOOD FLOW STUDIES IN MAN IN SHOCK.

Descriptive Note : Final technical rept. Jun 68-May 69,

Corporate Author : GOTEBORG UNIV (SWEDEN)

Personal Author(s) : Lewis,David H.

Report Date : JUN 1969

Pagination or Media Count : 80

Abstract : Soft tissue trauma to the hind leg of the dog causes an immediate but transient impairment of the ability of the skeletal muscle vasculature to respond to sympathetic vasoconstrictor tone. In hemorrhagic shock and after induced red cell aggregation there is a reduction in the capillary transport function of the skeletal muscle vasculature out of proportion to the reduction in capillary blood flow. Complete cessation of renal blood flow for up to 12 hours is compatible with subsequent normal hemodynamics and renal function provided the organ is properly perfused and stored in the cold. Removal of all of the formed elements of the blood by cell free perfusion of the kidney is not obtainable, but the best results are had with Dextran-40. Soft tissue trauma to the hind leg of the dog reduces renal blood flow but does not apparently cause a redistribution of intrarenal blood flow such that nutritional flow decreases out of proportion to the overall flow reduction. Liver transplantation in the pig with short ischemia times does not impair subsequent hepatic hemodynamics. Ex-vivo perfusion of human colons, even after brief periods of ischemia, yields lower flows than those obtained in situ. Soft tissue trauma to the hind leg of the dog causes a trapping of platelets in the lung. (Author)

Descriptors :   (*SHOCK(PATHOLOGY), *BLOOD CIRCULATION), HEMORRHAGE, TRANSPORT PROPERTIES, BLOOD PLATELETS, MUSCULOSKELETAL SYSTEM, LIVER, KIDNEYS, GASTROINTESTINAL SYSTEM, NERVE IMPULSES, STIMULATION(PHYSIOLOGY), TRANSPLANTATION, SWEDEN

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE