Accession Number : AD0694433

Title :   THE ROLE OF NUTRITION IN VESICAL CALCULUS FORMATION.

Descriptive Note : Rept. no. 4 (Final), 1 Apr 67-31 Mar 69,

Corporate Author : VIRGINIA POLYTECHNIC INST BLACKSBURG DEPT OF BIOCHEMISTRY AND NUTRITION

Personal Author(s) : Bunce,George E.

Report Date : SEP 1969

Pagination or Media Count : 12

Abstract : Dietary studies have shown that a ration low in phosphorous, thiamine, riboflavin and pyridoxine and high in carbohydrate, when fed to young rats for fifteen weeks, results in an approximately 40% incidence of formation of one or more calculi of sufficient size (1-3 mm diameter) to be readily visible to the unaided eye. Both bladder and kidney stones were observed although the former were predominant. Supplementation of the test diets with four times the minimal requirements of each of these vitamins prevented stone formation. It appears that the low phosphorous diet can be useful in the assessment of the influence of nutrients upon stone formation. Studies with the Orion calcium ion activity electrode have led to the development of satisfactory techniques for the measurement of activity in rat urine. The value of such measurements in the study of the mechanisms of calculogenesis can now be determined. The data obtained so far have not been prepared for publication. Experiments are underway designed to confirm and extend the initial results of the influence of thiamine, riboflavin and pyridoxine on stone genesis and to test the relationship of calcium ion activity to stone genesis. (Author)

Descriptors :   (*CALCULI, *NUTRITION), DIET, METABOLISM, PHYSIOLOGY, KIDNEYS, DISEASES, RATS, PHOSPHORUS, THIAMINES, VITAMIN B COMPLEX, PYRIMIDINES, CALCIUM

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE