Accession Number : AD0695567

Title :   METABOLISM OF SERUM FREE FATTY ACID AND LOW-DENSITY LIPOPROTEINS IN THE COLD-ACCLIMATED RAT,

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT TORONTO DOWNSVIEW (ONTARIO)

Personal Author(s) : McBurney,Linda J. ; Radinski,M. W.

Report Date : 07 AUG 1968

Pagination or Media Count : 5

Abstract : Albumin-bound palmitate-1-14C was injected intravenously into groups of cold-acclimated (4 C) and control (22 C) rats. The appearance of the palmitate-1-14C label in the triglyceride (TG) fraction of the liver and serum lipids was followed for 90 min after injection. No difference in the levels of radioactivity in the liver TG was found between the two groups of animals, but recovery of the label in the serum TG was lower in the cold-acclimated rat. When Triton was injected intravenously 5 min after an initial injection of palmitate-1-14C, the resulting accumulation of serum TG and radioactivity was higher in control animals than in corresponding acclimated rats. In a second study, 14C-labeled FFA, very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) labeled mainly in the TG fraction were injected into both groups of animals. Fractional turnover rates of FFA, VLDL, and LDL were higher in the cold-acclimated rats than in the corresponding control animals. Serum volume was higher in the cold-acclimated rats but the calculated turnover of VLDL was reduced to 48% of that found for the control group. (Author)

Descriptors :   (*FATTY ACIDS, METABOLISM), (*METABOLISM, LIPOPROTEINS), LABELED SUBSTANCES, ACCLIMATIZATION, RATS, LIVER, BLOOD SERUM, BLOOD CHEMISTRY, GLYCEROLS, BIOSYNTHESIS

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE