Accession Number : AD0696103

Title :   EFFECT OF INJECTED PARGYLINE UPON OPERANT AVOIDANCE IN THE MONKEY,

Corporate Author : AEROMEDICAL RESEARCH LAB (6571ST) HOLLOMAN AFB N MEX

Personal Author(s) : Whitney,Glayde D. ; Craig,Daniel J. ; Hanly,W. Carey ; Batson,Paul Y.

Report Date : OCT 1969

Pagination or Media Count : 20

Abstract : Pargyline-HCl is of interest as a possible therapeutic agent in the treatment of decaborane intoxication. Decaborane in low doses is known to have severe disruptive effects upon instrumental behavior. Pargyline, in order to qualify as a therapeutic agent, must not itself lead to severe behavioral disruption. In this study each of five monkeys was given a single intraperitoneal injection of buffered suspension of pargyline, the dosage being equivalent to 45 mg pargyline-HCl/kg of body weight. Their behavior was evaluated for four days following injection on a concurrent free-operant avoidance schedule with two superimposed discriminated avoidance tasks. In no cases were pargyline-induced changes in behavior of sufficient magnitude to affect the efficiency of shock avoidance. It is concluded that the effect of pargyline on these behaviors is quantitatively slight in comparison to the effects of decaborane recorded in the literature, and that behavioral disruption from pargyline itself need not be the major consideration in decisions relevant to the therapeutic use of pargyline-HCl for decaborane induced behavioral intoxication. (Author)

Descriptors :   (*DECABORANES, TOXICITY), (*ROCKET PROPELLANTS, TOXICITY), DOSAGE, PRIMATES, BEHAVIOR, REACTION(PSYCHOLOGY), NITRILES, AMINES

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE