Accession Number : AD0696174

Title :   THE ROLE OF INHIBITION IN INFORMATION TRANSFER. PART 2. THE INTERACTION OF CENTRIFUGAL AND CENTRIPETAL STIMULATION ON NEURONES OF THE COCHLEAR NUCLEUS.

Descriptive Note : Final rept. (Part 2),

Corporate Author : BIRMINGHAM UNIV (ENGLAND) NEUROCOMMUNICATIONS RESEARCH UNIT

Personal Author(s) : Whitfield,I. C. ; Comis,S. D.

Report Date : 30 SEP 1966

Pagination or Media Count : 38

Abstract : The micro-tap technique has been used to apply pharmacologically active substances to neurones of the cochlear nucleus. Neither strychnine nor picrotoxin had any influence on centripetally induced inhibition, so that no light is thrown on the question of whether such inhibition might be pre- or post-synaptic. Acetylcholine has been shown to have a uniformly excitatory, and noradrenaline an inhibitory action on cells of the cat cochlear nucleus. Evidence is presented that the centrifugal pathway from the lateral superior olive to the cochlear nucleus may be cholinergic. Electrical stimulation of this pathway lowers the threshold of ventral cochlear nucleus neurones to sound stimuli. Electrical stimulation of the nuclei of the lateral lemniscus produces predominantly inhibition of individual neurones of the contralateral cochlear nucleus, though in some circumstances excitation is seen. The nature of the centrifugal cochlear mechanism is discussed. (Author)

Descriptors :   (*NERVE CELLS, STIMULATION(PHYSIOLOGY)), CNS STIMULANTS, ELECTROPHYSIOLOGY, NERVOUS SYSTEM, PHYSIOLOGY, ACETYLCHOLINE, LEVARTERENOL, GREAT BRITAIN

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE