Accession Number : AD0696417

Title :   STUDIES ON STORED LIQUID WHOLE BLOOD. II. EFFECT OF VOLUME TRANSFUSED ON IN VIVO SURVIVAL MEASUREMENT.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Shields,Charles E.

Report Date : 01 AUG 1969

Pagination or Media Count : 14

Abstract : Selected isotope doses were used to label progressively larger volumes of blood. The percent label was as satisfactory as the small volume control if incubation time was increased. Adequate labeling was usually achieved by 2 hours and not significantly increased with any further practical increases in incubation time. The immediate posttransfusion radioactivity of the large volume group samples matched those from the small volume control group, suggested label stability, and showed a similarity of response within the circulation. The transfusion studies involved blood stored for different time periods and little difference was detected in the survival values of large and small volume groups. The survival results were similar between autologous and non-autologous transfusions. Blood from units supplemented with adenine had higher survival levels at each storage period compared to blood from units collected in ACD alone. Thus, the survival test based on isotope labeling is not subject to marked interference from the volume infused or the form of transfusion as long as the blood is carefully crossmatched, but it is sensitive to changes in red cell preservation during storage and is a useful test for comparing different blood preservative solutions. (Author)

Descriptors :   (*BLOOD, STORAGE), (*BLOOD TRANSFUSION, VOLUME), EFFICIENCY, IN VIVO ANALYSIS, LABELED SUBSTANCES, ERYTHROCYTES, PRESERVATION

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE