Accession Number : AD0697374

Title :   NOMOGRAMS CORRELATING DOSE OF MMH WITH BLOOD LEVELS.

Descriptive Note : Final rept. May-Nov 69,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Smith,Edwin B. ; Clark,Dale A.

Report Date : SEP 1969

Pagination or Media Count : 13

Abstract : Nomograms were developed to show the interrelationship of time and dose to methemoglobinemia or plasma monomethyl hydrazine (MMH) concentration as observed during the first 2 hours after application of MMH to the chest of anesthetized male dogs. Limitations of the nomograms are discussed in respect to range and accuracy. It is emphasized that the nomograms were compiled from responses of anesthetized dogs. These nomograms could be used to estimate the severity of human exposure only in conjunction with other known MMH intoxication symptoms. In the absence of dose-response data from humans, however, the nomograms are considered the best available data by which to evaluate accidental exposure by skin contact with MMH. (Author)

Descriptors :   (*METHYL HYDRAZINES, TOXICITY), (*SKIN(ANATOMY), METHYL HYDRAZINES), DOSAGE, EXPOSURE(PHYSIOLOGY), NOMOGRAPHS, TOXIC TOLERANCES, DOGS, RESPONSE(BIOLOGY), TIME, HYDRAZINE DERIVATIVES, BLOOD CHEMISTRY

Subject Categories : Biochemistry
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE