Accession Number : AD0697375

Title :   ELECTRON MICROSCOPIC STUDIES ON ANIMALS EXPOSED TO DIFFERENTIAL POTENTIAL SPACECRAFT ENVIRONMENTS.

Descriptive Note : Final rept. Jun 66-Sep 68,

Corporate Author : TEXAS UNIV GALVESTON MEDICAL BRANCH

Personal Author(s) : Marshall,Richard B. ; Roberts,Daniel K. ; Turner,Robert A. ; Gordon,Donald L.

Report Date : AUG 1969

Pagination or Media Count : 38

Abstract : Groups of male rats were exposed to 100% oxygen at 380 mm. Hg pressure and to normal atmosphere at ground level. They were sacrificed at 2-week intervals throughout the exposure period. Biochemical studies showed a pituitary adrenal response after 1 week of exposure to 100% oxygen at 380 mm. Hg pressure, returning toward control level after 3 weeks. Noise stress experienced by some of the animals after 7 weeks of exposure to 100% oxygen resulted in a marked rise in plasma corticoids. In animals exposed for 1 week, no alteration of ultrastructure was seen in the pituitary and only minimal alteration was seen in the adrenals. Pituitaries of the experimental rats exposed for 5 weeks showed no ultrastructural evidence of change. Adrenal cortical cells from these animals showed an increase in dense lipid and mitochondrial change at 1, 3, and 5 weeks of exposure. Pituitaries of rats stressed after 7 weeks of exposure showed ultrastructural evidence of secretory release from increased number of adrenal corticotrophic cells with a cytologic change in the fasciculata cells of the adrenal glands. (Author)

Descriptors :   (*SPACE ENVIRONMENTS, ANIMALS), (*PATHOLOGY, ELECTRON MICROSCOPY), (*ELECTRON MICROSCOPY, SPACE BIOLOGY), SPACECRAFT, SPACE BIOLOGY, OXYGEN, POISONING, BAROMETRIC PRESSURE, HISTOLOGY, BIOCHEMISTRY, PITUITARY GLAND, ADRENAL GLANDS, ADRENAL CORTEX, CELLS(BIOLOGY)

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE