Accession Number : AD0698044

Title :   HEMORRHAGIC SHOCK AND ADRENAL CORTEX.

Descriptive Note : Progress rept. no. 2 (Annual), 1 Jul 68-30 Jun 69,

Corporate Author : BOSTON UNIV MASS SCHOOL OF MEDICINE

Personal Author(s) : Egdahl,Richard H.

Report Date : SEP 1969

Pagination or Media Count : 34

Abstract : A method for the study of the microcirculatory pattern of the adrenal gland is described. In control animals there is a uniform appearance of the cortical vasculature. In hemorrhagic shock vasoconstruction in the pre-capillary arterioles of the capsular plexus occurs, resulting in a patchy gross appearance of the cortex. Microscopically numerous segments of the cortical capillary bed did not receive the injection material suggesting relative non-perfusion of these areas. The kidney plays a quantitatively major role in the metabolism of insulin and growth hormone; most of the removal occurs by degradation in the renal tissue, and not by urinary excretion. There is a constant relationship between the arterial hormone concentration and the renal arterio-venous hormone difference over a wide range of concentrations. The renal arterio-venous difference of insulin and growth hormone in acute hemorrhagic shock, studies over a wide range of arterial concentrations, is the same in magnitude as in the control studies. Differences in concentration in aortic and portal venous blood of dogs and monkeys showed clearance of corticosteroid by the gut. Percentage of corticosteroid removed was higher in animals during shock than in controls. There was a linear relationship between the amount removed and arterial corticosteroid concentrations. (Author)

Descriptors :   (*ADRENAL CORTEX, *SHOCK(PATHOLOGY)), PATHOLOGY, PHYSIOLOGY, BLOOD CIRCULATION, KIDNEYS, METABOLISM, INSULIN, HORMONES, CORTICOSTEROID AGENTS, GROWTH(PHYSIOLOGY), HISTOLOGY, HEMORRHAGE

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE