Accession Number : AD0698467

Title :   TOXOGONIN: BLOOD LEVELS AND SIDE EFFECTS AFTER INTRAMUSCULAR ADMINISTRATION IN MAN.

Descriptive Note : Technical rept.,

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Sidell,Frederick R. ; Groff,William A.

Report Date : DEC 1969

Pagination or Media Count : 25

Abstract : Toxogonin, when given intramuscularly to 10 healthy young men, produced blood levels of oxime more than five times higher than those produced by equimolar doses of 2-PAMCl. Associated side effects included tachycardia, hypertension, and dose independent symptom complex consisting of a peroral warmth, paresthesia and hypalgesia, and a menthol taste. Some of the published data on the relative effectiveness of Toxogonin and 2-PAMCl, reviewed in the light of the current study, offer substantial reasons for further inquiry into Toxogonin's therapeutic potential. (Author)

Descriptors :   (*CHEMICAL WARFARE AGENTS, *PARASYMPATHOMIMETIC AGENTS), (*OXIMES, PARASYMPATHOMIMETIC AGENTS), HUMANS, BLOOD PRESSURE, BLOOD CHEMISTRY, PATHOLOGY, DOSAGE, TOXICITY, TOXIC TOLERANCES, HEMATOLOGY, PYRIDINES

Subject Categories : Medicine and Medical Research
      Toxicology
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE