Accession Number : AD0698478

Title :   CHROMIUM COMPLEXES OF INSULIN AND RELATED COMPOUNDS.

Descriptive Note : Final rept. 1 Jun 63-31 Aug 69,

Corporate Author : MARYLAND UNIV COLLEGE PARK DEPT OF CHEMISTRY

Personal Author(s) : Rollinson,Carl L. ; Rosenbloom,Eleanor W.

Report Date : DEC 1969

Pagination or Media Count : 35

Abstract : The method of sequential dialysis has been developed by which biological compounds can be efficiently evaluated in this respect. The method has been used extensively in studying the reactions of Cr(III), which is essential to the functioning of insulin, with many biological ligands including amino acids, bases, biological phosphates, most of the compounds of the Krebs cycle and many of the glycolytic chain. The most effective form compounds with Cr(III) having constant rates of transport through membranes for several days. Among these are citrate, isocitrate, mesoxalate, tartronate, ADP, ATP, thiamine pyrophosphate, histidine, fructose-1,6-diphosphate and 3-phosphoglycerate. Work in progress includes extension of these studies to additional biological ligands, different concentrations of reactants and essential metal ions other than Cr(III). (Author)

Descriptors :   (*INSULIN, *COMPLEX COMPOUNDS), (*CHROMIUM COMPOUNDS, INSULIN), (*DIALYSIS, COMPLEX COMPOUNDS), CHELATE COMPOUNDS, PHOSPHATES, ADENINE, AMINO ACIDS, ALCOHOLS, GLYCOLYSIS

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE