Accession Number : AD0698816
Title : PHYSICAL CHARACTERISTICS OF SYNTHETIC AND NERVE MEMBRANES.
Descriptive Note : Final rept., 1 Nov 66-31 Dec 68,
Corporate Author : WEIZMANN INST OF SCIENCE REHOVOTH (ISRAEL) POLYMER DEPT
Personal Author(s) : Katchalsky,Aharon ; Miller,Israel R.
Report Date : JUL 1969
Pagination or Media Count : 45
Abstract : The research on this project was carried out along two closely related lines: One line of investigation was devoted to the theoretical analysis of transport processes across membranes using nonequilibrium thermodynamics. In the framework of this project chemicodiffusional coupling was considered and applied to facilitated or carrier transport. The second line of investigation was essentially experimental in approach. (a) In an attempt to construct a well defined model for very thin biological membranes, the kinetic coefficients for ion permeability through monolayers were determined. The monolayers were adsorbed at the interface between a mercury electrode and water, and the ionic permeability measured polarographically. By this method the transport of Cu(++) across a decylammonium monolayer and its dependence on temperature was investigated. (B) The transport of ions across a composite double membrane was measured as a function of the applied potential. In a membrane composed of cation and anion exchange elements in series, the ionic distribution was studied, and the results analyzed by the methods of nonequilibrium thermodynamics. (Author)
Descriptors : (*MEMBRANES, TRANSPORT PROPERTIES), (*NERVES, *MEMBRANES(BIOLOGY)), PERMEABILITY, THERMODYNAMICS, DIFFUSION, COPPER COMPOUNDS, AMMONIUM COMPOUNDS, CHEMICAL EQUILIBRIUM, PHOSPHOLIPIDS, LIPOPROTEINS, ISRAEL
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE