Accession Number : AD0698885

Title :   CHANGES IN THE REFLEX TIME, SPONTANEOUS MOTOR ACTIVITY, PHYSICAL ENDURANCE AND EFFICIENCY OF ANIMALS UNDER THE INFLUENCE OF RADIOPROTECTIVE AGENTS,

Corporate Author : FORT DETRICK FREDERICK MD

Personal Author(s) : Bodakva,A. P.

Report Date : 12 JAN 1970

Pagination or Media Count : 9

Abstract : Cystamine and N,N'-tetramethylcystamine (TMC) in doses of 25 and 50 mg/kg induce suppression of the reflex function of the spinal cord. N,N'-difurfurylcystamine (DFC) induces a moderate lengthening of the time of the latent period of the flexion reflex in rabbits but only in a dose of 50 mg/kg. Rapid intravenous injection of rabbits with large doses of cystamine and TMC causes toxic phenomena which are not observed when the preparations are injected slowly. Cystamine, TMC and DFC in doses of 10, 50, 100 and 150 mg/kg depress the motor activity and physical endurance of white mice. Moreover, as dosages of the preparations are increased, the effect of their action increases. Cystamine and DFC in doses of 10, 50 and 100 mg/kg reduce the static efficiency of white mice. (Author)

Descriptors :   (*RADIOPROTECTIVE AGENTS, RESPONSE(BIOLOGY)), REFLEXES, ENDURANCE(PHYSIOLOGY), RABBITS, DOSAGE, TOXICITY, CENTRAL NERVOUS SYSTEM, INJECTIONS(MEDICINE), INHIBITION, MICE, USSR

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE