Accession Number : AD0699380

Title :   COMPUTER SIMULATION OF A LIVING CELL: MULTILEVEL CONTROL SYSTEMS.

Descriptive Note : Technical rept.,

Corporate Author : MICHIGAN UNIV ANN ARBOR LOGIC OF COMPUTERS GROUP

Personal Author(s) : Weinberg,Roger ; Zeigler,Bernard P.

Report Date : DEC 1969

Pagination or Media Count : 49

Abstract : A simple bacterial cell (Escherichia coli) has been modeled, and the input-output behavior of the model has been simulated as a program in FORTRAN IV for an IBM 360/67 digital computer. Automata theoretic analysis of the homomorphic model underlying the computer simulation enables us to investigate the information content and complexity of the simulation and of the measurement space representing our data base. The simulated cell is able to adjust its enzymes and DNA to grow in different chemical environments using allosteric modification of enzymes, and repression of RNA synthesis. It grows at realistic rates and achieves limited metabolic stability. (Author)

Descriptors :   (*ESCHERICHIA COLI, MATHEMATICAL MODELS), (*CELLS(BIOLOGY), MATHEMATICAL MODELS), BIONICS, COMPUTER PROGRAMMING, CYTOCHEMISTRY, GENETICS, ENZYMES, METABOLISM, INFORMATION THEORY, GROUPS(MATHEMATICS), MAPPING(TRANSFORMATIONS), SYSTEMS ENGINEERING, SIMULATION

Subject Categories : Bionics

Distribution Statement : APPROVED FOR PUBLIC RELEASE