Accession Number : AD0699554

Title :   SIMULATION OF THE RENAL EFFECTS OF ANTIDIURETIC HORMONE (ADH) IN MAN,

Corporate Author : RAND CORP SANTA MONICA CALIF

Personal Author(s) : DeHaven,J. C. ; Shapiro,N. Z.

Report Date : NOV 1969

Pagination or Media Count : 68

Abstract : A biomathematical model incorporating the actions of antidiuretic hormone on urine flow and composition is presented. Body compartments representing intracellular and interstitial fluid as well as plasma, red cells and respiratory volume are simulated. Urine formation, including concentration ratios produced by the kidney through glomerular and tubular functions, is treated via a compartment separated from the body by an active membrane. The composition and rate of urine flow are influenced both by the level of antidiuretic hormone in plasma and by the chemical reactions within and between body compartments, including urine. During dynamic response to stress, the current antidiuretic hormone level in the model is established by the previous history of hormone production, by excretion and destruction, and by the current plasma volume. The validity of the model was tested by imulating rapid ingestion of large amounts of water. The transient responses of the model compare favorably with results obtained in human subjects given a water load. (Author)

Descriptors :   (*HORMONES, DIURETICS), (*KIDNEYS, PHYSIOLOGY), SIMULATION, URINE, MATHEMATICAL MODELS, STRESS(PHYSIOLOGY), WATER, INGESTION(PHYSIOLOGY)

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE