Accession Number : AD0699793

Title :   EFFECTS OF PHENOTHIAZINES ON CERTAIN BIOCHEMICAL PARAMETERS OF THE HUMAN RED CELL DURING STORAGE.

Descriptive Note : Final rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Kocholaty,Walter F. ; Bowles-Ledford,Edith ; Billings,Thomas A. ; Goetz-Daly,Joyce ; Gray,John L.

Report Date : 08 SEP 1969

Pagination or Media Count : 22

Abstract : Various concentrations of four closely related phenothiazine derivatives were added to CPD blood under blood banking conditions and their effect on various enzymes, intermediates, and on the composition of the cell membrane was studied. Of all the parameters investigated, the most significant findings were the levels of 2,3-DPG and ATP which were found to be significantly higher in the presence of chlorpromazine than in the controls during prolonged storage. Of the four phenothiazines investigated, only chlorpromazine exhibited this property. (Author)

Descriptors :   (*BLOOD, STORAGE), (*ERYTHROCYTES, *PHENOTHIAZINES), METABOLISM, PRESERVATION, CONCENTRATION(CHEMISTRY), ENZYMES, CELL STRUCTURE, ADENOSINE PHOSPHATES, CHLORPROMAZINE

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE