Accession Number : AD0699867

Title :   SEROTONIN AND OTHER VASOACTIVE AGENTS IN EXPERIMENTAL DECOMPRESSION SICKNESS,

Corporate Author : UNIVERSITY OF WESTERN ONTARIO LONDON DEPT OF PHARMACOLOGY

Personal Author(s) : Clark,M. L. ; Philp,R. B. ; Gowdey,C. W.

Report Date : 20 JUN 1969

Pagination or Media Count : 4

Abstract : A number of vasoactive agents were screened for their effects on the indidence and severity of decompression sickness in rats by a standardized bends-inducing procedure involving compression, decompression, and exercise at altitude. None of the substances in the dosage schedules used altered the incidence of bends, but serotonin markedly increased the severity. This result is interesting in view of recent observations from this laboratory on the role of platelets in decompression sickness. (Author)

Descriptors :   (*SEROTONIN, DECOMPRESSION SICKNESS), (*VASOACTIVE AGENTS, DECOMPRESSION SICKNESS), RATS, EXERCISE(PHYSIOLOGY), DOSAGE, CHEMOTHERAPEUTIC AGENTS, BLOOD ANALYSIS, TOXICITY, BLOOD CIRCULATION, MORTALITY RATES, CANADA

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE