Accession Number : AD0700204

Title :   ACTION OF PYRIDINE-2-ALDOXIME METHOCHLORIDE (PAM) ON THE RECTUS ABDOMINIS MUSCLE OF THE FROG,

Corporate Author : MONTREAL UNIV (QUEBEC) FACULTE DE PHARMACIE

Personal Author(s) : Goyer,G. Robert

Report Date : 04 JUN 1969

Pagination or Media Count : 7

Abstract : The neuromuscular action of pyridine-2-aldoxime methochloride (PAM) was evaluated in vitro on the frog rectus abdominis muscle. Dose-response curves were obtained from eserinized and noneserinized preparations, with acetylcholine and succinylcholine as the agonists. It was possible to demonstrate the dualistic activity of PAM, i.e. a facilitating and a depressing effect. From the present study it can be concluded that the facilitation observed with the lower concentrations is closely related to the anticholinesterasic activity of PAM, whereas the depressing effect seen when higher concentrations are used can be associated with a noncompetitive mechanism of inhibition. (Author)

Descriptors :   (*OXIMES, *SKELETAL MUSCLE RELAXANTS), AMPHIBIANS, PARASYMPATHOMIMETIC AGENTS, CHLORIDES, PYRIDINES, ACETYLCHOLINE, CANADA

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE