Accession Number : AD0700255

Title :   HYDRODYNAMIC ANALYSIS OF THE FILTRATION HYPOTHESIS OF LIPID DEPOSITION IN THE GENESIS OF ARTERIOSCLEROSIS.

Descriptive Note : Technical rept.,

Corporate Author : HYDRONAUTICS INC LAUREL MD

Personal Author(s) : Brown,Clinton E. ; Tulin,Marshal P. ; Van Dyke,Peter

Report Date : JAN 1970

Pagination or Media Count : 38

Abstract : As early as 1933, Anitschkow proposed that slow filtration of fluid through the arterial walls resulted in trapping of high molecular weight lipids and that such trapping and accumulation might constitute the mechanism for the genesis of arteriosclerosis. In the present paper this filtration hypothesis is examined in the light of modern experience in fluid mechanics and rheology and it is shown that under normal conditions of flow and shear stress the lipid concentration at the walls whould be only slightly greater than that in the blood bulk. However, in regions of stasis or in regions where the shearing rate falls to low values, filtration may result in large amplification of the bulk concentration of lipids such that wall tissue concentrations are greatly elevated. The analysis takes into account the filtration current through the wall and the effect of increasing viscosity and diminishing diffusion with increased concentration. The resulting set of non-linear differential equations was solved on a high speed digital computer. (Author)

Descriptors :   (*ATHEROSCLEROSIS, HYDRODYNAMICS), (*BLOOD CIRCULATION, LIPIDS), (*LIPIDS, DEPOSITION), ETIOLOGY, CONCENTRATION(CHEMISTRY), ARTERIES, THEORY, FLUID FLOW, PERMEABILITY, DIFFUSION

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE