Accession Number : AD0700727

Title :   CORNEAL ENDOTHELIUM IN VITRO: GROWTH INHIBITION AND STRUCTURAL CHANGES INDUCED BY HYDROCORTISONE.

Descriptive Note : Final rept., 67-69,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Lowry,George M.

Report Date : NOV 1969

Pagination or Media Count : 15

Abstract : Corneal endothelium from young albino rabbits was grown in tissue culture in the presence of supraphysiologic concentrations of hydrocortisone. Examination of the cultured cells by light- and electron microscopy disclosed abnormalities in mitochondria, endoplasmic reticulum, cytoplasmic granules, and nuclear chromatin. Although hydrocortisone impaired outgrowth, a given number of corneal endothelial cells grown in the presence of hydrocortisone covered more surface area on the growth substrate than did an equal number of control cells. (Author)

Descriptors :   (*CORNEA, CELLS(BIOLOGY)), (*CELLS(BIOLOGY), *CORTICOSTEROID AGENTS), (*TISSUE CULTURE, CORNEA), IN VITRO ANALYSIS, MITOCHONDRIA, CYTOPLASM, GROWTH(PHYSIOLOGY), INHIBITION, MORPHOLOGY(BIOLOGY), PATHOLOGY, NUCLEI(BIOLOGY)

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE