Accession Number : AD0701080

Title :   A MODEL OF HIPPOCAMPAL CA3 CIRCUITRY.

Descriptive Note : Interim scientific rept. no. 6,

Corporate Author : MICHIGAN STATE UNIV EAST LANSING DIV OF ENGINEERING RESEARCH

Personal Author(s) : Kilmer,William L. ; McLardy,Turner

Report Date : 07 JAN 1970

Pagination or Media Count : 44

Abstract : The paper discusses the structure and function of the hippocampus, particularly its CA3 sector, and presents a design of a functional model of CA3 that is being studied to discover ways in which its circuit relations may account for its presumed functions. A model of the pyramid-basket cells circuitry was designed and is being studied by computer simulation. It comprises 7 pyramids, 5 basket cells, and a cross-correlative masory element at each basket cell axon collateral toward a pyramid. The circuit behavior is described by first-order nonlinear differential equations, time delay parameters, and trainable nonlinear logic functions. Problems being studied include trade-offs between simultaneous over-all training methods and local training waves, and between inhibitory averaging by basket cells and locally specific learning in basket cell distribution systems. A CA3 time binding capability allows not only temporal integration but also a markovian element in CA3's output even if no CA1 or other cortex is present. (Author)

Descriptors :   (*BRAIN, MODELS(SIMULATIONS)), PHYSIOLOGY, CENTRAL NERVOUS SYSTEM, NERVE IMPULSES, NERVE CELLS, BEHAVIOR, NONLINEAR SYSTEMS, CIRCUITS

Subject Categories : Bionics

Distribution Statement : APPROVED FOR PUBLIC RELEASE