Accession Number : AD0701097

Title :   METABOLIC CORRELATES OF THE MEAL ONSET IN THE FREE FOOD INTAKE OF RATS.

Descriptive Note : Final technical rept. Oct 68-Sep 69,

Corporate Author : ECOLE PRATIQUE DES HAUTES ETUDES PARIS (FRANCE) NATURALIA ET BIOLOGIA

Personal Author(s) : Le Magnen,Jacques

Report Date : OCT 1969

Pagination or Media Count : 30

Abstract : Metabolic correlates of the onset and of the frequency of meals as main determinants of the caloric regulation of food intake have been investigated in rats. The suggestion that this onset occurs at a critical threshold of the exhaustion of the caloric supply provided by the preceding meal has been tested by a simultaneous recording of respiratory exchanges and free feeding patterns. The detailed analysis of 13 Dark-Light 24 hour cycles has shown that rats displayed a D-L cycle of fat synthesis and fat mobilization parallel to and accounting for the cycle of intake. In the nocturnal period, the onset of meals anticipated the complete exhaustion of the preceding food supply, leading, in this period, to a definite and measured hyperphagia. In the light period, the onset of meals was delayed and occurred at a maximal level of lipolysis and a minimal level of the utilization of calories derived from ingested food. The resulting hypophagia compensated the nocturnal hyperphagia and was the primary cause of the concomitant fat synthesis. By contrast, the immediate increase of food intake in the light period, induced by the injection of anti-lipolytic drugs or hormones (propranolol and insulin) provide evidence that the normal fall of food intake in this period resulted from the oxidation of mobilized free fatty acids. Implications of these results regarding the nature of humoral signals of hunger and satiety are discussed. (Author)

Descriptors :   (*INGESTION(PHYSIOLOGY), *METABOLISM), FOOD, CALORIMETRY, FATS, BIOSYNTHESIS, INSULIN, DIURNAL VARIATIONS, PERCEPTION, RATS, HORMONES, FRANCE

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE