Accession Number : AD0701170

Title :   EFFECT OF LYSERGIC ACID DIETHYLAMIDE ON Escherichia coli, STRAIN B/r(lambda).

Descriptive Note : Technical rept. Jan 68-Feb 69,

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Dowler,Michael J. ; Wolpert ,Jack S.

Report Date : FEB 1970

Pagination or Media Count : 22

Abstract : The effect of LSD on E. coli was examined as a test system for damage to genetic material. LSD had a dose-dependent effect on bacterial growth rate. This effect was not amplified by the DNA-repair inhibitor caffeine. The lowering of the growth rate by LSD was shown to be completely reversible upon dilution. LSD was shown to cause a dose dependent extension of the growth recovery lag due to UV damage. Caffeine caused a much larger extension of this lag time. (Author)

Descriptors :   (*LYSERGIC ACIDS, *ESCHERICHIA COLI), GROWTH(PHYSIOLOGY), CHROMOSOMES, DAMAGE, DOSAGE, PURINE ALKALOIDS, ULTRAVIOLET RADIATION, DEOXYRIBONUCLEIC ACIDS, INHIBITION, HALLUCINOGENS, CHEMICAL WARFARE AGENTS, BIOASSAY

Subject Categories : Biochemistry
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE