Accession Number : AD0701170
Title : EFFECT OF LYSERGIC ACID DIETHYLAMIDE ON Escherichia coli, STRAIN B/r(lambda).
Descriptive Note : Technical rept. Jan 68-Feb 69,
Corporate Author : EDGEWOOD ARSENAL MD
Personal Author(s) : Dowler,Michael J. ; Wolpert ,Jack S.
Report Date : FEB 1970
Pagination or Media Count : 22
Abstract : The effect of LSD on E. coli was examined as a test system for damage to genetic material. LSD had a dose-dependent effect on bacterial growth rate. This effect was not amplified by the DNA-repair inhibitor caffeine. The lowering of the growth rate by LSD was shown to be completely reversible upon dilution. LSD was shown to cause a dose dependent extension of the growth recovery lag due to UV damage. Caffeine caused a much larger extension of this lag time. (Author)
Descriptors : (*LYSERGIC ACIDS, *ESCHERICHIA COLI), GROWTH(PHYSIOLOGY), CHROMOSOMES, DAMAGE, DOSAGE, PURINE ALKALOIDS, ULTRAVIOLET RADIATION, DEOXYRIBONUCLEIC ACIDS, INHIBITION, HALLUCINOGENS, CHEMICAL WARFARE AGENTS, BIOASSAY
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE