Accession Number : AD0702470

Title :   IDENTIFICATION OF PHOTODYNAMIC SYSTEMS IN THE RETINA.

Descriptive Note : Final scientific rept. 1 Oct 68-30 Jun 69,

Corporate Author : SASSARI UNIV (ITALY) INST OF BIOLOGICAL CHEMISTRY AND GENERAL PATHOLOGY

Personal Author(s) : Santamaria,Leonida

Report Date : 30 JUN 1969

Pagination or Media Count : 14

Abstract : The retina lesions caused by light (so called 'solar retinitis') is not related to a heat effect due either to the collimation of infra-red rays or to the transformation in heat of visible light by absorption from the pigment layer. Our data on isolated calf retina demonstrated for the first time that light produces an oxygen dependent damage of the retina respiratory enzymes. The present final scientific report refers to the demonstration that: (a) the reciprocity law i x t = k (i is the intensity of light, and t is the exposure time) holds for the photodynamic sensitivity of the retina; (b) the threshold dosage of such a sensitivity is about 200,000 erg/(sq cm) for isolated bovine retina; (c) the chromophores active in producing the damage are in the range of 320-380 nm and 380-500 nm. (Author)

Descriptors :   (*RETINA, WOUNDS AND INJURIES), PATHOLOGY, LIGHT, INTENSITY, EXPOSURE(PHYSIOLOGY), PHOTOSENSITIVITY(BIOLOGICAL), THRESHOLDS(PHYSIOLOGY), EYE, RESPONSE(BIOLOGY), ITALY

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE