Accession Number : AD0702668

Title :   A STUDY OF THE VARIABILITY OF THE CHIKUNGUNJA VIRUS. REPORT I. A NEW FACTOR AFFECTING THE MANIFESTATION OF THE PLAQUE-SIZE CRITERION,

Corporate Author : FORT DETRICK FREDERICK MD

Personal Author(s) : Zasukhina,G. D. ; Marinina,V. T.

Report Date : 03 FEB 1970

Pagination or Media Count : 7

Abstract : A new factor was discovered, which affects the plaque-size criterion for the Chikungunja virus: the age of the tissue culture. In a 120-hour old tissue culture the virus population has a homogeneous small-plaque characteristic, in distinction from the heterogeneous, basically large-plaque population in 48-hour old tissue cultures. This phenomenon is linked to a longer duration of the replication cycle on the basis of 'old' cells and does not depend upon the action of inhibitors of the sulfonated polysaccharide type. In 'young' tissue cultures, a sensitivity of the majority of the small-plaque variants to inhibitors has been detected. No differences have been established between large- and small-plaque variants of the virus with respect to adsorption properties and duration of the replication cycle. The small-plaque variant possesses a greater capacity for reproduction than does the large-plaque variant. (Author)

Descriptors :   (*CHIKUNGUNYA VIRUS, TISSUE CULTURE), (*TISSUE CULTURE, AGING(PHYSIOLOGY)), SENSITIVITY, MUTATIONS, GROWTH(PHYSIOLOGY), IN VITRO ANALYSIS, ARBOVIRUSES, ADSORPTION, USSR

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE