Accession Number : AD0705063

Title :   PULMONARY COMPLICATIONS FOLLOWING LIVER TRAUMA,

Descriptive Note : Technical rept.,

Corporate Author : OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY

Personal Author(s) : McCurdy,W. C. ; Hawley,W. D. ; Coalson,J. J. ; Greenfield,L. J.

Report Date : 12 DEC 1969

Pagination or Media Count : 20

Abstract : Progressive pulmonary insufficiency has been observed clinically in two patients after hepatic trauma and was associated temporally with the manipulation of the organ necessary for operative repair. In dogs subjected to a standardized liver contusion, depression of pulmonary mechanics, arterial PO2, and surfactant were observed after infusions of simple extracts of hepatic tissue or bile. No damage was noted after hepatic injury alone. Light and electron microscopy showed edema, hemorrhage, and destruction of capillary endothelium in both groups although more alveolar cell damage was noted after liver extract infusion suggesting an additional toxin. Many factors may operate to facilitate lung damage, and the vulnerability of the lung to liver products suggests increased attention to ventilatory support following repair of hepatic injuries. Survival of one clinical case was facilitated by the use of an expiratory resistor in association with positive-pressure ventilation. (Author)

Descriptors :   (*LIVER, WOUNDS AND INJURIES), (*LUNG, PATHOLOGY), RESPIRATORY SYSTEM, HISTOLOGY, EDEMA, HEMORRHAGE, CELLS(BIOLOGY), RESPIRATION

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE