Accession Number : AD0705069

Title :   COMPARISON OF SEPTIC SHOCK DUE TO GRAM-NEGATIVE AND GRAM-POSITIVE ORGANISMS.

Descriptive Note : Technical rept.,

Corporate Author : OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY

Personal Author(s) : Guenter,Clarence A. ; Hinshaw,Lerner B.

Report Date : 31 MAR 1970

Pagination or Media Count : 14

Abstract : Cardiorespiratory effects of gram-negative and gram-positive septicemia were compared in the lightly anesthetized rhesus monkey. Thirty to 60 minutes after the onset of infusion of organisms, the cardiac output was higher and the peripheral resistance lower in the group that received staphylocci, as compared to the group that received E. coli. Subsequently, the cardiac output decreased, systemic pressure decreased, minute ventilation increased, alveolo-arterial oxygen tension gradients increased and arterial PCO2 and bicarbonate decreased as previously described in septic shock and to a comparable degree in both groups. These findings suggest a common host response to gram-positive and gram-negative organisms. (Author)

Descriptors :   (*SEPTICEMIA, *SHOCK(PATHOLOGY)), CARDIOVASCULAR SYSTEM, RESPIRATORY SYSTEM, BACTERIA, STAPHYLOCOCCUS, ESCHERICHIA COLI, BLOOD PRESSURE, BLOOD VOLUME, PHYSIOLOGY, PATHOLOGY

Subject Categories : Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE