Accession Number : AD0706442

Title :   THE EFFECTS OF P-2-AM ON THE RELEASE OF ACETYLCHOLINE FROM THE ISOLATED DIAPHRAGM OF THE RAT,

Corporate Author : MONTREAL UNIV (QUEBEC) FACULTE DE PHARMACIE

Personal Author(s) : Goyer,Robert G.

Report Date : 26 JUN 1969

Pagination or Media Count : 5

Abstract : Release of acetylcholine from rat isolated diaphragm preparations stimulated through the phrenic nerve was investigated in the presence of P-2-AM 0.01-100 mM. At 1 mM, the release of acetylcholine was increased by 157%, while higher concentrations resulted in a decrease. The findings indicate that the biphasic action of P-2-AM can be explained, at least in part, by variations in the quantal release of acetylcholine--an effect involving a presynaptic action. (Author)

Descriptors :   (*OXIMES, *ACETYLCHOLINE), CHOLINESTERASE, STIMULATION(PHYSIOLOGY), IN VITRO ANALYSIS, DIAPHRAGMS(ANATOMY), NEUROMUSCULAR TRANSMISSION, MUSCLES, RATS, NERVOUS SYSTEM, CANADA

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE