Accession Number : AD0706867

Title :   ENZYME STUDIES ON PRIMATES: EVOLUTIONARY TRENDS AND PHYSIOLOGICAL SIGNIFICANCE (A SUMMARY OF FINDINGS).

Descriptive Note : Final rept. 15 Oct 68-15 Oct 69,

Corporate Author : WAYNE STATE UNIV DETROIT MICH SCHOOL OF MEDICINE

Personal Author(s) : Goodman,Morris ; Koen,Ann L.

Report Date : MAY 1960

Pagination or Media Count : 15

Abstract : Several enzymes and their isozymes were compared among primates, and some conclusions were drawn regarding evolutionary advancement. The enzymes examined included lactate dehydrogenase, aconitase, isocitrate dehydrogenase, phosphoglucomutase, glucose-6-phosphate dehydrogenase, and 6-phosphogluconate dehydrogenase. In-depth studies were conducted on lactate dehydrogenase. Results indicated that there is some difference in muscle-type lactate dehydrogenase between the chimpanzee and man which is not revealed by electrophoretic migration; that the ratio of heart/muscle type lactate dehydrogenase increases with ascension of the evolutionary scale; and that there may be two loci coding for the heart-type subunit in the slow loris. (Author)

Descriptors :   (*ENZYMES, *PRIMATES), (*GENETICS, ENZYMES), MONKEYS, HUMANS, MUSCLES, HEART, OXIDOREDUCTASES, LACTATES

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE