Accession Number : AD0707669

Title :   THE CHEMISTRY AND PHARMACOLOGY OF CERTAIN COMPOUNDS AFFECTING THE CENTRAL NERVOUS SYSTEM OF ANIMALS AND MAN.

Descriptive Note : Summary progress rept. no. 2,

Corporate Author : MICHIGAN UNIV ANN ARBOR DEPT OF PHARMACOLOGY

Personal Author(s) : Hardman,Harold F. ; Domino,Edward F. ; Seevers,Maurice H.

Report Date : JAN 1957

Pagination or Media Count : 54

Abstract : The extensive actions of tetrahydrocannabinol derivatives upon the cardiovascular system suggest that these agents act by inhibition of the afferent to efferent areas of the central components of the sympathetic nervous system. Behavioral changes characterized by CNS depression, ataxia, analgesia and enhanced tendon reflexes have been described. The general toxicity of the tetrahydrocannabinol derivatives is discussed as well as the effects of drugs which antagonize or potentiate their pharmacological actions. An analysis of structure activity relationship is presented for the tetrahydrocannabinol derivatives evaluated in this study.

Descriptors :   (*PSYCHOTROPIC AGENTS, PHARMACOLOGY), (*CANNABIS, *CENTRAL NERVOUS SYSTEM), (*RESERPINE, CENTRAL NERVOUS SYSTEM), CARDIOVASCULAR SYSTEM, BEHAVIOR, TOXICITY, PATHOLOGY, PHYSIOLOGY, PHARMACOLOGY, DOSAGE, ANIMALS, HUMANS, NERVOUS SYSTEM, SLEEP, DOGS

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE