Accession Number : AD0707985

Title :   EFFECTS OF ALTITUDE ON CELLULAR METABOLISM AND TERMINAL OXIDATION.

Descriptive Note : Rept. no. 2 (Annual), 15 Apr 69-14 Apr 70,

Corporate Author : HOWARD UNIV WASHINGTON D C DEPT OF PHYSIOLOGY

Personal Author(s) : Costello,Leslie C. ; Gold,Armand J.

Report Date : MAY 1970

Pagination or Media Count : 14

Abstract : The report presents continuation studies of the effects of altitude exposure on energy metabolism and mitochondrial activity in rats. Exposure of rats in experimental chambers at a simulated altitude of 25000 ft. resulted in a consistent elevated plasma pyruvate. The animals under these conditions developed hypophagia, weight loss, and increased hematocrits. Isolated liver and kidney mitochondria from these animals did not exhibit any alterations in cytochrone oxidase activity, respiratory control ratio, or ADP/O ratio. However state 4 respiration of kidney mitochondria was significantly and consistently decreased in altitude animals. (Author)

Descriptors :   (*HIGH ALTITUDE, *METABOLISM), (*CELLS(BIOLOGY), HIGH ALTITUDE), (*MITOCHONDRIA, HIGH ALTITUDE), HYPOXIA, EXPOSURE(PHYSIOLOGY), PYRUVATES, BLOOD PLASMA, HEMATOCRIT, BODY WEIGHT, BAROMETRIC PRESSURE, TISSUES(BIOLOGY), OXIDATION, OXIDOREDUCTASES, STRESS(PHYSIOLOGY)

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE