Accession Number : AD0708321

Title :   EFFECT OF RIBONUCLEASE ON PROPAGATION OF HOOF AND MOUTH DISEASE. REPORT II: EFFECT OF RIBONUCLEASE ON THE INFECTION PROCESS IN EXPERIMENTAL HOOF AND MOUTH DISEASE,

Corporate Author : ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER WASHINGTON D C

Personal Author(s) : Salganik,R. I. ; Batalina,T. A. ; Nogina,V. T. ; Slapoguzova,A. S. ; Mosolov,A. N.

Report Date : 17 APR 1970

Pagination or Media Count : 18

Abstract : Ribonuclease does not change the infectious properties of native hoof and mouth disease virus and does not prevent the absorption and penetration of this virus into cells. The preincubation of cells with ribonuclease does not change their capacity for ensuring the process of replication of viral particles. Ribonuclease evidently acts directly on the RNA of the replicating virus. The absence of inhibiting activity of desoxyribonuclease and trypsin in the concentrations used in this study, which considerably exceed the possible quantity of impurities, precludes the possibility of attributing the observed effect to the presence of these enzymes in the ribonuclease employed. Ribonuclease prevents the replication of this virus in the organism of suckling mice and safeguards the animals from death. The report II deals with the testing of ribonuclease enzyme as a specific method of prophylaxis and treatment in experimental hoof and mouth disease. Tests were conducted on newborn rabbits and guinea pigs. (Author)

Descriptors :   (*FOOT AND MOUTH DISEASE VIRUS, *RIBONUCLEASE), VIRUS DISEASES, INFECTIOUS DISEASES, VIRUSES, ENTEROVIRUSES, GROWTH(PHYSIOLOGY), RIBONUCLEIC ACIDS, ENZYMES, IMMUNITY, THERAPY, LABORATORY ANIMALS, USSR

Subject Categories : Animal Husbandry and Veterinary Medicine
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE