Accession Number : AD0708941

Title :   MECHANISMS OF HEMOLYSIS.

Descriptive Note : Annual summary rept.,

Corporate Author : CALIFORNIA UNIV SAN DIEGO LA JOLLA

Personal Author(s) : Bernstein,Eugene F.

Report Date : JUN 1970

Pagination or Media Count : 60

Abstract : Following cell-wall interaction trauma, relatively few erythrocytes are immediately lysed. A much larger number are significantly damaged and undergo later destruction in vivo, or autohemolysis in vitro. The mechanism of this damage includes an increase in the oxidative metabolic cycle, and selective lipid elution. Lysolecithin activity and lipid peroxidation do not appear to be important mechanisms. Further studies of erythrocyte metabolic pathways, particularly in relationship to ATP and 2, 3-DPG, appear to be indicated to clarify their role in the progressive metabolic degeneration of the damaged erythrocyte membrane. (Author)

Descriptors :   (*HEMOLYSIS, PHYSIOLOGY), ERYTHROCYTES, METABOLISM, OSMOTIC PRESSURE, PHOSPHOLIPIDS, PEROXIDES, VITAMIN E, LIPIDS, GLUCOSE, CONSUMPTION, OXIDATION, DAMAGE, BIOCHEMISTRY, MEMBRANES(BIOLOGY)

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE