Accession Number : AD0709424
Title : A DIPEPTIDYL CARBOXYPEPTIDASE THAT CONVERTS ANGIOTENSIN I AND INACTIVATES BRADYKININ.
Descriptive Note : Technical rept.,
Corporate Author : OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY
Personal Author(s) : Yang,H. Y. T. ; Erdos,E. G. ; Levin,Y.
Report Date : 23 JUN 1970
Pagination or Media Count : 9
Abstract : While studying the inactivation of bradykinin, it was noticed that in addition to carboxypeptidase N, a second enzyme, kininase II, cleaved the peptide. The latter enzyme hydrolyzed the Pro7-Phe8 gond in bradykinin and thus liberated the C-terminal phenylalanylarginine dipeptide. Because kininase II acted as a dipeptidyl carboxypeptidase (DCP), a study was made of its relation to the angiotensin I converting enzyme that liberates a histidylleucine dipeptide from the decapeptide and thereby converts it into the active octapeptide angiotensin II. (Author)
Descriptors : (*BLOOD PROTEINS, *ENZYMES), PEPTIDE HYDROLASES, PEPTIDES, HYDROLYSIS
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE