Accession Number : AD0709424

Title :   A DIPEPTIDYL CARBOXYPEPTIDASE THAT CONVERTS ANGIOTENSIN I AND INACTIVATES BRADYKININ.

Descriptive Note : Technical rept.,

Corporate Author : OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY

Personal Author(s) : Yang,H. Y. T. ; Erdos,E. G. ; Levin,Y.

Report Date : 23 JUN 1970

Pagination or Media Count : 9

Abstract : While studying the inactivation of bradykinin, it was noticed that in addition to carboxypeptidase N, a second enzyme, kininase II, cleaved the peptide. The latter enzyme hydrolyzed the Pro7-Phe8 gond in bradykinin and thus liberated the C-terminal phenylalanylarginine dipeptide. Because kininase II acted as a dipeptidyl carboxypeptidase (DCP), a study was made of its relation to the angiotensin I converting enzyme that liberates a histidylleucine dipeptide from the decapeptide and thereby converts it into the active octapeptide angiotensin II. (Author)

Descriptors :   (*BLOOD PROTEINS, *ENZYMES), PEPTIDE HYDROLASES, PEPTIDES, HYDROLYSIS

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE