Accession Number : AD0709740

Title :   INHIBITION OF ELECTRON AND ENERGY TRANSFER IN MITOCHONDRIA BY STEROIDS.

Descriptive Note : Final scientific rept. 1 Nov 67-31 Oct 69,

Corporate Author : CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS BUENOS AIRES (ARGENTINA)

Personal Author(s) : Stoppani,Andres O. M.

Report Date : 01 JUN 1970

Pagination or Media Count : 55

Abstract : Studies with highly selective inhibitors of mitochondrial respiration, such as amytal, rotenone and piericidin have largely contributed to elucidate the mechanism of electron transfer at the NADH-dehydrogenase region of the respiratory chain. These studies prompted a comparison of steroid effects with those of the above cited inhibitors. For that purpose, 19-nor-ethynyltestos-terone acetate (NEA) was chosen because, (1) with submitochondrial particles (Keilin-Hartree preparation), NEA is one of the most potent steroidal inhibitors of electron transfer (4), and (2) NEA is used in humans as a oral regulator of fertility. (Author)

Descriptors :   (*MITOCHONDRIA, RESPIRATION), (*STEROIDS, MITOCHONDRIA), HORMONES, INHIBITION, ENZYMES, ARGENTINA

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE