Accession Number : AD0710198

Title :   WHOLE BODY BASE EXCESS: ACUTE RESPONSE TO ACID-BASE STRESS IN THE DOG,

Corporate Author : RAND CORP SANTA MONICA CALIF

Personal Author(s) : Russell,C. D. ; Roeher,H. D. ; Illickal,M. M. ; Deland,E. C. ; Maloney,J. V. , Jr

Report Date : MAY 1970

Pagination or Media Count : 37

Abstract : A crucial problem in the clinical treatment of a variety of pathological states is to determine the acid-base status of the patient. Usually the acid-base status of a sample of blood in vitro, which can easily be determined, is used as a rough index of the status of the body, but the relation between the two has not been thoroughly explored. This study derives the correlation between the arterial-blood composition and the acid-base status of the whole body over a range of experimental conditions in which both respiratory and metabolic status were changed simultaneously. A nomogram for estimating whole body base excess from the pH an pCO2 of arterial blood has been constructed from experimental data obtained in 54 nephrectomized dogs subjected to hyperventilation, CO2 breathing, NaHCO3 infusion, HCl infusion, and NH4Cl infusion in varying combinations. The data correlation was assisted by a general theoretical model of fluid and electrolyte distribution in the whole body, implemented on a digital computer. (Author)

Descriptors :   (*BLOOD CHEMISTRY, PH FACTOR), (*PH FACTOR, MEASUREMENT), HUMAN BODY, DIAGNOSIS(MEDICINE), BIOCHEMISTRY, PHYSIOLOGY, PATHOLOGY, IN VITRO ANALYSIS, COMPUTERS, SIMULATION, MODELS(SIMULATIONS), CORRELATION TECHNIQUES, DOGS

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE