Accession Number : AD0710700

Title :   INTERRELATIONS OF SLEEP AND FOCAL EPILEPTIFORM DISCHARGE IN MONKEYS WITH ALUMINA CREME LESIONS.

Descriptive Note : Final rept. 2 Jan-4 Nov 69,

Corporate Author : WASHINGTON UNIV SEATTLE SCHOOL OF MEDICINE

Personal Author(s) : Frank,G. S. ; Pegram,G. Vernon

Report Date : JUL 1970

Pagination or Media Count : 33

Abstract : Intra cortical alumina creme foci were used to study interrelations of sleep and epileptiform discharge in monkeys. Ten to 200 micro-liter injections produced actively discharging lesions in superior frontal and posterior middle temporal gyri, but no epileptiform activity could be induced in anterior frontal pole, superior temporal gyrus, or occipital areas. Clear differences in discharge density were seen in the active lesions. The temporal foci were maximally active during stage REM while frontal foci were quiescent during stage REM and maximally active during Stages 1 and 2 sleep. Though the number of animals with actively discharging lesions was small, the study does suggest some anatomic specificity of both epileptogenicity and sleep-discharge relations. (Author)

Descriptors :   (*SLEEP, *EPILEPSY), (*ELECTROPHYSIOLOGY, EPILEPSY), CONVULSIVE DISORDERS, ALUMINUM COMPOUNDS, HYDROXIDES, BRAIN, MONKEYS, CEREBRAL CORTEX

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE