Accession Number : AD0711016

Title :   EFFECT OF ACUTE HEMORRHAGE ON ARTERIAL AND VENOUS RESISTANCE.

Descriptive Note : Technical rept.,

Corporate Author : OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY

Personal Author(s) : Brobmann,Guenther F. ; Ulano,Harvey B. ; Moore,George ; Meyer,Paul ; Brecher,Gerhard A.

Report Date : 24 JUL 1970

Pagination or Media Count : 20

Abstract : Early hemodynamic responses to rapid hemorrhage were studied in anesthetized open chest dogs to test whether Leo Sapirstein's hypothesis is correct that an increase in venous resistance leads to shock after hemorrhage instead of an increase in arterial resistance. Electromagnetic blood flow transducers were used to measure cardiac output in the ascending aorta and venous return in the superior and inferior venae cavae. Systemic arterial, peripheral and central venous pressures were measured with strain gauges, and venous pressures were also measured with water manometers. Rapid removal of 30% of the blood volume caused significant (p< .05) decreases in all measurements. Conclusions about initial hemodynamic responses to massive hemorrhage are: (1) total peripheral resistance decreased, (2) large vein resistance to flow, venous return, increased, and (3) the increase in venous resistance was not affected by alpha-adrenergic blockade. The increase in large vein resistance with hemorrhage suggests that the combination of the vis a fronte (force attracting blood into the heart) and a decreasing vis a tergo (force driving blood from arterial system into the veins) may bring about a partial collapse of the large veins. (Author)

Descriptors :   (*HEMORRHAGE, *CARDIOVASCULAR SYSTEM), PATHOLOGY, PHYSIOLOGY, BLOOD VESSELS, BLOOD CIRCULATION, BLOOD PRESSURE, HEART, BLOOD VOLUME, SHOCK(PATHOLOGY), RESPONSE(BIOLOGY), AUTONOMIC NERVOUS SYSTEM

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE