Accession Number : AD0711044

Title :   EFFECT OF NITROGEN TRIFLUORIDE ON PLASMA CONCENTRATIONS OF LACTATE, METHEMOGLOBIN, AND SELECTED ENZYMES.

Descriptive Note : Rept. for Apr-Jun 68,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Coppoc,Gordon L. ; Leger,Shelton J.

Report Date : JUL 1970

Pagination or Media Count : 12

Abstract : Blood samples of rats exposed to high concentrations of nitrogen trifluoride were analyzed for concentrations of serum glutamic oxalacetic transaminase (SGOT), serum isocitric dehydrogenase (ICDH), blood lactate, and methemoglobin. Inhalation of 10,000 p.p.m. NF3 for 45 minutes resulted in the conversion of 37% of the total rat hemoglobin to methemoglobin and a 6-fold increase in blood lactate at the end of exposure. Both parameters had returned to normal 4 hours later. Serum isocitric dehydrogenase did not change detectably as a result of the exposure. Serum glutamic oxalacetic transaminase was unchanged at 1 hour, but was increased 2- to 3-fold by 6 hours postexposure and remained elevated for as long as 24 hours after the exposure. (Author)

Descriptors :   (*FLUORIDES, *TOXICITY), BLOOD PLASMA, NITROGEN COMPOUNDS, ENZYMES

Subject Categories : Biochemistry
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE