Accession Number : AD0711552

Title :   ANTIGENIC AND BIOLOGICAL CLASSIFICATION OF DENGUE VIRUSES.

Descriptive Note : Final rept. 1 Nov 66-31 Oct 69,

Corporate Author : YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE

Personal Author(s) : Downs,Wilbur G. ; Halstead,Scott B. ; Casals,Jordi ; Shotwell,Henry

Report Date : 01 JUN 1970

Pagination or Media Count : 53

Abstract : Dengue viruses are the cause of two distinct diseases, dengue fever (DF), a mild and self limited illness and dengue hemorrhagic fever (DHF), a severe disease with an appreciable mortality rate. This investigation addressed itself to the hypothesis that two subpopulations of dengue viruses exist, virulent and avirulent, and that the virulence of a dengue infection is correlated with identifiable antigenic markers on the virus. In addition, an attempt was made to evaluate in sub-human primates the hypothesis that a second dengue infection is modified by host factors to result in more severe disease response. (Author)

Descriptors :   (*DENGUE, VIRUSES), (*VIRUSES, CLASSIFICATION), ANTIGENS + ANTIBODIES, VIRUS DISEASES, INFECTIOUS DISEASES, ARBOVIRUSES, FEVERS, SERODIAGNOSIS, PATHOLOGY, MONKEYS

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE