Accession Number : AD0711554

Title :   EFFECTS OF CERTAIN COMPOUNDS ON ANIMALS SUBJECTED TO SIMULATED HIGH ALTITUDE.

Descriptive Note : Rept. no. 3 (Final), 20 Oct 69-31 Jul 70,

Corporate Author : PITTSBURGH UNIV PA

Personal Author(s) : Buckley,Joseph P. ; Barry,Herbert , III ; El Masry,Souheir

Report Date : AUG 1970

Pagination or Media Count : 26

Abstract : There was a 50% reduction in hepatic glycogen content of male Wistar rats treated with phenformin hydrochloride, 100 mg/kg, or decompressed for 4 hours at 24,000 feet. There was also an increase in the glycogen content of the heart and diaphragm of the decompressed animals. There was a 5-fold increase in the myocardial glycogen content of rats treated with phenformin for 7 days as well as a marked increase in glycogen content in both the liver and diaphragm. Blood lactate increased approximately 3-fold following phenformin treatment and approximately 8-fold after a single dose of phenformin plus 4 hours of decompression. The data suggest that prolonged treatment with phenformin enhances the efficiency of recycling carbohydrate under anaerobic conditions and increases utilization of carbohydrate at the expense of lipid stores. (Author)

Descriptors :   (*GUANINE, HYPOXIA), (*HYPOXIA, HIGH ALTITUDE), (*CHEMOTHERAPEUTIC AGENTS, HYPOXIA), CHEMOTHERAPY, DECOMPRESSION, LIVER, GLYCOGEN, GLUCOSE, PYRUVATES, LACTATES, BLOOD, SIMULATION, TABLES(DATA), INSULIN

Subject Categories : Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE