Accession Number : AD0711584

Title :   COMPARATIVE STUDY OF ANTIMALARIAL AND OTHER DRUGS ON G6PD DEFICIENT RED CELLS.

Descriptive Note : Final technical rept. May 69-May 70,

Corporate Author : GENOA UNIV (ITALY) ISTITUTO DI CLINICA MEDICA

Personal Author(s) : Salvidio,E. ; Pannacciulli,I. ; Ajmar,F. ; Paravidino,G. ; Gaetani,G.

Report Date : JUN 1970

Pagination or Media Count : 47

Abstract : The effects of various dosages of DFD (Di-N-formyl-diaminophenyl sulfone) on normal and G6PD (Glucose-6 phosphate dehydrogenase) deficient red cells belonging to 25 Sardinian and Negro donors and transfused into 30 normal recipients were studied. (1) Single dosages of DFD, from 400 to 1200 mg, have definite hemolytic effects on G6PD deficient, not on normal red cells. (2) The destruction of the G6PD deficient red cells by DFD is dose related. (3) The borderline dosages are different if one deals with red cells belonging to G6PD deficient Sardinians or Negroes. (4) The G6PD deficient red cells belonging to Negroes are destroyed by single dosages of DFD around 800 mg. (6) Methemoglobinemia in normal recipients, receiving DFD increased only after the administration of single dosages of 1200 and 800 mg of the drug. (Author)

Descriptors :   (*ANTIMALARIALS, ERYTHROCYTES), (*ERYTHROCYTES, *OXIDOREDUCTASES), NUTRITIONAL DEFICIENCY DISEASES, PLASMODIUM, DISEASES, DRUGS, DOSAGE, HEMOLYSIS, CINCHONA ALKALOIDS, PHARMACOLOGY, BLOOD DISEASES

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE