Accession Number : AD0712179

Title :   THE POSSIBLE MEDIATION BY CYCLIC AMP OF THE STIMULATION OF THYMOCYTE PROLIFERATION BY VASOPRESSIN AND THE INHIBITION OF THIS MITOGENIC ACTION BY THYROCALCITONIN,

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGY

Personal Author(s) : Whitfield,J. F. ; MacManus,J. P. ; Gillan,D. J.

Report Date : 15 APR 1970

Pagination or Media Count : 12

Abstract : Lysine vasopressin (antidiuretic hormone), like cyclic adenosine 3',5'-monophosphate (cyclic AMP), rapidly (in less than 1 hour) stimulates the initiation of deoxyribonucleic acid synthesis and thereby increases the flow of cells into mitosis in rat thymic lymphocyte populations in vitro. This mitogenic action of vasopressin, again like that of cyclic AMP, is potentiated by caffeine, an inhibitor of the intracellular phosphodiesterase which catalyzes the degradation of cyclic AMP. On the other hand, vasopressin's mitogenic action (also like that of cyclic AMP) is blocked by imidazole, an activator of cyclic nucleotide phosphodiesterase activity. The hormone, thyrocalcitonin (calcitonin) which is known to block the cyclic AMP-mediated mitogenic effect of parathyroid hormone by interfering with cyclic AMP action, also blocks the mitogenic action of vasopressin. The inhibitory effects of imidazole and thyrocalcitonin on vasopressin's mitogenic action are both overcome by the phosphodiesterase inhibitor, caffeine. It is concluded from these observations that the mitogenic action of vasopressin is mediated by cyclic AMP. (Author)

Descriptors :   (*LYMPHOCYTES, MITOSIS), (*MITOSIS, INHIBITION), (*HORMONES, MITOSIS), CELLS(BIOLOGY), PHYSIOLOGY, THYMUS, ADENOSINE PHOSPHATES, STIMULATION(PHYSIOLOGY), GROWTH(PHYSIOLOGY), DEOXYRIBONUCLEIC ACIDS, PURINE ALKALOIDS, PITUITARY HORMONES, THYROID HORMONES, IN VITRO ANALYSIS, CANADA

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE