Accession Number : AD0712379

Title :   INABILITY OF SUCCINATE TO PROTECT RATS FROM THE CHRONIC EFFECTS OF HYPERBARIC OXYGEN TOXICITY,

Corporate Author : NAVAL AIR DEVELOPMENT CENTER JOHNSVILLE PA AEROSPACE MEDICAL RESEARCH DEPT

Personal Author(s) : Kowalski,M. K. ; Ashley,Archie ; Kydd,G. H.

Report Date : 23 SEP 1970

Pagination or Media Count : 21

Abstract : Rats of the Sprague-Dawley strain were succinate protected toward the acute effects (convulsions) of oxygen toxicity and exposed to 5 ata, 100% oxygen to ascertain if protection also existed against the chronic effects (paralysis). The data obtained on 18 succinate-injected rats as compared with 18 corresponding controls indicated that no significant resistance to paralysis was present. Thus paralysis due to OHP did not require previous convulsive episodes. The continuous monitoring of body temperature, measured rectally throughout the exposure presented no correlation between convulsions and temperature variation. However, a characteristic type of temperature decrease did appear directly preceding or with the onset of paralyses. This characteristic temperature profile was essentially the same for both the succinate-protected and non-protected rats during the exposure in which paralyses occurred, indicating the mechanistic centers of temperature control and paralyses were affected similarly by OHP and that succinate did not influence these centers significantly. (Author)

Descriptors :   (*OXYGEN, TOXICITY), (*SUCCINATES, OXYGEN), PRESSURE BREATHING, STRESS(PHYSIOLOGY), THERAPY, PROTECTION, CONVULSIVE DISORDERS, PARALYSIS, PHYSIOLOGY, BODY TEMPERATURE, RATS

Subject Categories : Medicine and Medical Research
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE